Nicotine, also known as nicotine, is a viscous colorless or light yellow oily liquid, which mainly exists in Solanaceae plants. Nicotine is a physiological stimulant, which spreads to the whole body through the lung mucosa and oral mucosa. After entering the brain, it binds to nicotinic acetylcholine receptors (nAChRs) on the surface of many neurons, causing the release of neurotransmitters such as dopamine, which will make people feel excited and happy and reduce anxiety and tension.

At present, studies have shown that nicotine plays a positive role in the treatment of Parkinson’s disease, Alzheimer’s disease, schizophrenia, ulcerative colitis and depression to a certain extent.

At present, nicotine products on the market are mainly natural nicotine, which is extracted from tobacco raw materials. It contains some impurities, mainly impurities formed by degradation and some trace alkaloid impurities, such as neonicotinic alkali, quinone, cotinine, myosmine β- Diene nicotine, nicotine-n-oxide, etc. Affected by the origin and quality of raw materials, the types and contents of impurities in natural nicotine products will be different. Because these impurities in natural nicotine extraction products are very close to nicotine, it is difficult to remove them in technology. The European Pharmacopoeia, British Pharmacopoeia and American Pharmacopoeia also limit the content of nicotine impurities to varying degrees.

In addition, nicotine extracted from tobacco has bad smell, bitter taste, strong volatility, and is easily oxidized to dark red in the air, which greatly limits its application.

At present, the research on the Synthetic Nicotine mainly focuses on the Synthetic Nicotine salt and nicotine complex. A Synthetic Nicotine salt disclosed in patent cn107536099a and a preparation method thereof; Patent cn108323791a discloses a nicotine zinc oxide complex, a preparation method thereof and a tobacco product comprising the same; Patent cn109619655a discloses a compound nicotine salt and its solution, a preparation method and application thereof; Patent cn109171010a discloses liquid nicotine and a preparation method thereof. However, these patents are based on nicotine extracted from tobacco sources, which has many of the above problems.

Patent cn107011321a discloses a preparation method of synthetic racemic nicotine, which successfully synthesized high-purity racemic nicotine, which shows that nicotine can be synthesized through chemical path. However, there are few reports on the application of Synthetic Nicotine products.

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Nicotine, also known as nicotine, is a viscous colorless or light yellow oily liquid, which mainly exists in Solanaceae plants. Nicotine is a physiological stimulant, which spreads to the whole body through the lung mucosa and oral mucosa. After entering the brain, it binds to nicotinic acetylcholine receptors (nAChRs)...