San Diego-based Next Generation Labs LLC (NGL), is the market leader in the still relatively nascent Synthetic Nicotine arena. “We are often considered the poor cousin of other [Synthetic Nicotine] suppliers, when in fact we are the dominant and first player in the market,” insisted Ron Tully, one of the company’s co-founders. NGL supplies both the tobacco/vaping and pharmaceutical sectors with its TFN® and Pharmanic® branded Synthetic Nicotine products. However, the company’s customers are also using TFN® in a range of “smokeless” consumer products (see related story in this issue).

The gradual – if slow – shift from “natural” to Synthetic Nicotine that is currently happening particularly in the vaping sector has to be looked at from a risk reduction perspective. “[Vaping] Manufacturers are interested in eliminating tobacco residuals from nicotine, and consumers want as clean a nicotine as possible as they seek nicotine alternatives on their journey away from tobacco,” he explained.

“A chemically synthesized molecule is in many ways a more perfect version of its natural counterpart. Think synthetic diamonds versus natural diamonds,” Tully said. In the case of nicotine, the enantiomeric nature of the molecule allows the synthetic manufacturing process to isolate the specific characteristics of the S-, R/S-, and R-isomer mixtures. According to Tully, this potentially could open new avenues for supporting combinational reward pathway nicotine (R- and S-isomer adjusted ratios), rather than utilizing only tobacco-identical S-isomer nicotine in future consumer products. Next Generation Labs’ c.e.o., Vincent Schuman, added that the company “has taken the lead in developing this type of nicotine exploration, and will continue to do so going forward.”

Initially “starting with a very broad vision of redefining nicotine as a technology in multiple industry sectors,” the company’s two current Synthetic Nicotine brands were first launched in 2014, with TFN® now primarily targeting the vaping and “smokeless” industry (see product table). “We eventually homed in our focus on vape, tobacco, and pharmaceuticals, as these are the places where the company can have the greatest impact in finally giving manufacturers a non-tobacco choice about what to put in their products, while, at the same time, according adult consumers a choice about what nicotine is best for their individual lifestyles,” Tully elaborated.

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Synthetic NicotineSynthetic Nicotine is used for Quitting Smoking
San Diego-based Next Generation Labs LLC (NGL), is the market leader in the still relatively nascent Synthetic Nicotine arena. “We are often considered the poor cousin of other suppliers, when in fact we are the dominant and first player in the market,” insisted Ron Tully, one of the...