According to Swedish researchers, the use of e-cigarettes containing Synthetic Nicotine may immediately lead to increased blood clot formation and deterioration of small vessel dilation and dilation.

Synthetic Nicotine is considered to be the main culprit leading to the increase of thrombosis after the use of e-cigarettes,” Gustaf Lyytinen, M.D., a physician resident of Helsingborg hospital, a doctoral student of Karolinska medical school in Stockholm and dandred hospital, said at the International Conference of the European Respiratory Society on the Internet. “We can assume that this is due to the release of catecholamines and the activation of the sympathetic nervous system, or the increase in pulse and blood pressure seen in our study.”

Lyytinen and colleagues conducted a double-blind, randomized, crossover study of 22 healthy adults who reported occasional tobacco use. Each participant was tested before and after inhaling 30 e-cigarettes containing nicotine, and then before and after inhaling 30 e-cigarettes without nicotine. These tests were conducted separately for a period of 1 week.

Blood samples were obtained at baseline and 15 and 60 minutes after inhalation. Microcirculation was assessed at baseline and 30 minutes after inhalation using laser speckle contrast imaging and acetylcholine and sodium nitroprusside iontophoresis to assess endothelial dependent and independent pathways.

The researchers reported that platelet thrombosis (P =. 011) and fibrin rich thrombosis (P =. 035) increased significantly 15 minutes after participants used e-cigarettes containing synthetic nicotine. According to the results, these effects disappeared and returned to baseline after 60 minutes of exposure.

Lyytinen said that the use of e-cigarettes without Synthetic Nicotine had no effect on platelet formation.
The researchers observed that the peak microvascular flow unrelated to endothelium decreased significantly when nicotine atomized e-cigarette was used compared with baseline (P =. 009). However, no effect of endothelium-dependent microvascular flux was observed between e-cigarettes with or without nicotine.

In addition, there was no significant difference in microvascular function between e-cigarettes with or without Synthetic Nicotine.

These findings add to the current evidence base on the harmful effects of e-cigarettes and support the European Respiratory Society’s recommendation that smokers use other smoking cessation aids, such as patches or gum, without exposing their lungs to potentially toxic compounds.

“We can conclude that the steam containing Synthetic Nicotine in e-cigarettes has a direct impact on thrombosis, mainly the formation of platelet thrombosis, and also has an impact on vascular function. After use, the pulse and blood pressure rise,” Lyytinen said. “In addition, regular use of inhaled Synthetic Nicotine may affect vascular health.”

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According to Swedish researchers, the use of e-cigarettes containing Synthetic Nicotine may immediately lead to increased blood clot formation and deterioration of small vessel dilation and dilation. 'Synthetic Nicotine is considered to be the main culprit leading to the increase of thrombosis after the use of e-cigarettes,' Gustaf Lyytinen, M.D.,...