Comparison of technical routes for industrialized production of synthetic nicotine
1. Next Generation Labs, NGL Synthetic Nicotine: reacting nicotinate with N-vinyl-2-pyrrolidone in the presence of alkali and solvent to form a first mixture; Combining a first mixture with an acid to form a second mixture comprising a water layer; Separating the water layer from the second mixture; Combining the separated water layer with acid to form a third mixture; Combining a third mixture with a base to form a fourth mixture containing mesmin; Reducing mesamine to nornicotine with reducing agent; And methylated nornicotine to obtain R, s-nicotine. (domestic patent Publication No.: cn107406411a) nicotine manufactured using this patented process is called TFN ® Nicotine has entered the domestic market.
2. Jincheng Pharma Synthetic Nicotine: (a) 3-nicotinyl-1-vinyl-4,5-dihydro-1h-pyrrole-2-alcohol potassium was obtained by condensation of nicotinic acid ester and vinyl pyrrolidone under the condition of strong alkaline substances; (b) 3-nicotinyl-1-vinyl-4,5-dihydro-1h-pyrrole-2-alcohol potassium was refluxed and stirred in dilute acidic compounds to obtain mesmin (intermediate) in one pot; (c) The intermediate nicotine with high optical purity was obtained by catalytic reduction of mesmin in biological enzyme system; (d) The final product, l-nicotine, was obtained by ammonia methylation on the pyrrole ring of nornicotine. (Publication No.: cn112409327a, there are three other supporting patented technologies, which will release 200 tons of production capacity in the fourth quarter of this year and 500 tons next year)
3. Rundu Company Synthetic Nicotine: nicotine is prepared by esterification, synthesis, hydrolysis, amino protection, asymmetric oxidation, esterification, hydrolysis, cyclization, refining and sub packaging with 3-cyanopyridine (nicotinic nitrile and nicotinic nitrile) as starting materials. (no patent has been applied for, and production is planned to start in 2023)
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