A preparation method and process for producing synthetic nicotine from glutarate
The invention relates to the technical field of chemical synthesis, in particular to a method for producing Synthetic Nicotine from glutarate.
Nicotine, as one of the important active components of e-cigarette, mainly comes from tobacco extract and artificial chemical synthesis methods. Among them, nicotine extracted and purified from tobacco and other plants also contains other carcinogenic tobacco compound impurities, which is harmful to human health; Moreover, tobacco extract is more affected by raw materials and climate, so it is difficult to carry out large-scale industrial production. Synthetic nicotine has almost no other carcinogenic tobacco compound impurities, and can be produced on a large scale.
The preparation method of nicotine takes cyclic imine as the starting material, requires expensive chiral catalyst and high-pressure hydrogen equipment, and the production cost is high, so it is not suitable for large-scale industrial production. The patent Publication No. cn11233829a discloses a preparation method of optically active nicotine. Organic metal catalysts are prepared by using chiral ligands containing nitrogen or phosphorus, and Synthetic Nicotine is prepared by using imine derivatives as starting materials.
For the synthesis of nicotine, the preparation of organometallic catalysts is complex and the production cost is high.
The purity of Synthetic Nicotine is low.
Glutaric acid ester is a kind of raw material with wide source and low price, but there is no industrialized production of nicotine with glutaric acid ester as raw material at present
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